Natural GLP-1 Support
Let’s support your GLP-1 hormone and Butyrate in a Natural Way.
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GLP-1 Probiotic pro
How to Use
- Take one capsule daily with or without food.
- Pair with the Polyphenol Booster and consume a polyphenol-rich diet for optimal results.
- Store in the refrigerator for maximum potency.
Formula
This live probiotic is expertly designed to support women with abdominal pain and bloating!
- Active Ingredients: Clostridium butyricum WB-STR-0006 Bifidobacterium infantis Akkermansia muciniphila WB-STR-0001
- Inactive Ingredients: Microcrystalline cellulose, hypromellose (vegetarian capsule), fruit and vegetable juice (color), silica
- Encased in a plant-based, acid-resistant capsule, the active ingredients are delivered directly to the gut for maximum effectiveness.
Pendulum Pro products exclude all nine major allergens, ensuring safety and quality.
Side Effects
Mild digestive symptoms, such as gas or bloating, may arise but typically resolve within days to weeks. Noticeable microbiome improvements can be expected after 90 days of consistent use. Be aware that mild digestive discomfort (e.g., gas or bloating) may occur initially and should subside within days or weeks.
Do Not Use If…
This product should not be used by individuals allergic to any of its listed ingredients or by those who are immunocompromised. Always consult your healthcare provider to avoid potential interactions, especially if you are taking medications. Discontinue use and seek medical advice if you experience severe symptoms such as fever, abdominal pain, or blood in the stool.
polyphenol booster
How to Use
- Take two capsules daily with food.
- For best results, consume ~2 hours after dinner or before bedtime, as polyphenols may impact iron absorption from plant-based sources.
- Pair with the Akkermansia probiotic for enhanced microbiome support.
- Increase your intake of fiber-rich foods like nuts, fruits, and vegetables for optimal benefits.
- Store in a cool, dry place at room temperature; refrigeration is unnecessary.
Formula
Formula
This prebiotic powerhouse is specifically formulated to enhance women’s gut health by fostering a robust gut microbiota.
- Active Ingredients: Pomegranate extract, grape seed extract, green tea extract.
- Inactive Ingredients: Hypromellose (vegetarian capsule).
Pendulum products Pendulum Pro products exclude all nine major allergens, ensuring safety and quality.
Side Effects
Some users may experience temporary digestive changes such as gas, bloating, or altered bowel movements. As your body adjusts, these effects typically resolve within a few days to weeks. Noticeable improvements in your microbiome can take up to 90 days. Individual results will vary based on your health and unique microbiome composition.
Do Not Use If…
- Avoid if you are allergic to any listed ingredients.
- Consult with your GutsyRx doctor if you’re on medications like blood thinners (e.g., warfarin) or iron supplements, as polyphenols may impact iron absorption and interact with certain medications.
- Discuss the use of this supplement with your GutsyRx doctor before starting.
What Women Need To Know
About GLP-1 & Butyrate
Overview
Why Women’s Gut Health Needs Special Attention
Women are more likely to struggle with gut and metabolic issues, often due to imbalances in key hormones like GLP-1 and essential short-chain fatty acids like butyrate. These imbalances are associated with conditions such as celiac disease, colon cancer, inflammatory bowel disease, irritable bowel syndrome (IBS), metabolic syndrome, and overall poor gut health. [3] [5] [6]Yet, the medical system is often rushed and disease-focused, leaving women without the wellness-centered care they truly need.
The Power of GLP-1: Your Gut’s Metabolic Messenger
GLP-1 (glucagon-like peptide-1) is a hormone produced by intestinal L-cells in response to eating. It is key in appetite regulation, metabolism, and glucose balance. You may have heard of GLP-1 receptor agonist medications like Ozempic, Wegovy, and Zepbound, which enhance the effects of this hormone for weight loss and diabetes management. However, your body can naturally support GLP-1 production—and that starts in your gut.
Why GLP-1 Matters for Women’s Health
- Regulates Appetite & Reduces Food Noise: By naturally enhancing GLP-1, women can experience reduced cravings, more stable blood sugar, and improved satiety after meals.
- Boosts Insulin Sensitivity: GLP-1 helps cells utilize glucose efficiently, supporting balanced energy levels and metabolism.
- Supports Mood & Digestion: Many women report feeling less bloated, experiencing fewer cravings, and having a more stable mood when GLP-1 levels are optimized.
How to Naturally Enhance GLP-1
Your gut microbiome plays a huge role in supporting optimal GLP-1 levels. Specific beneficial gut bacteria, keystone strains, are essential for producing GLP-1. However, women often have lower levels of these microbes due to factors like chronic stress, hormonal shifts, and aging. By restoring keystone strains through targeted probiotics and gut-friendly nutrition, women can naturally support their body’s GLP-1 production—leading to better digestion, metabolism, and overall health.
Butyrate: The Unsung Hero of Gut & Hormonal Health
Butyrate is a powerful short-chain fatty acid produced when beneficial gut bacteria ferment dietary fiber. It is essential for gut health, metabolism, and overall well-being. Low butyrate levels have been linked to gut disorders, inflammation, and metabolic issues like PCOS and menopause-related weight gain.
The Benefits of Butyrate for Women
- Nourishes the Gut Lining: Butyrate strengthens the intestinal barrier, reducing the risk of leaky gut, IBS, and inflammation.
- Regulates Metabolism & Hormones: It supports insulin regulation, appetite control, and hormonal balance, making it particularly beneficial for women with PCOS, menopause-related symptoms, or metabolic syndrome.
- Enhances Gut-Brain Connection: Butyrate plays a key role in the gut-brain axis, helping to reduce stress, improve mood, and support cognitive health.
The Butyrate & GLP-1 Connection
One of the most exciting aspects of butyrate is its ability to stimulate GLP-1 production. When you increase butyrate levels, you simultaneously enhance GLP-1 activity, creating a powerful synergy for gut and metabolic health. By focusing on restoring butyrate-producing gut bacteria, women can achieve:
- Better digestion & reduced bloating
- More stable energy levels
- Improved insulin sensitivity & weight management
- Enhanced mental clarity & mood stability
Reasons For a Low GLP-1 and Butyrate Level in Women
- Chronic stress
- Diets high in processed foods and refined sugars
- Dysbiosis (Lack of butyrate-producing bacteria, low diversity)
- Endocrine disorders
- Frequent antibiotic use
- Hormonal fluctuations (e.g., perimenopause, menopause, PCOS)
- Inflammation
- Low resistant starch (e.g., green bananas, oats, beans)
- Low soluble fiber (e.g., apple, carrot, psyllium)
- Prolonged elimination diets
- Restrictive Diets
- Sedentary Lifestyle
- Sleep deprivation
Symptoms of a Low GLP-1 and Butyrate
This is a women-centric list of symptoms that can occur if GLP-1 and butyrate is low in the gut. This list does not encompass all the symptoms that can occur during GLP-1 and butyrate.
- Abdominal discomfort
- Aches and pains
- Bloating
- Brain Fog
- Constipation
- Diarrhea
- Evacuation issues
- Excessive flatulence (we all have flatulence)
- Food intolerance or food reactions
- Inflammation
- Irregular bowel movements
- Low energy
- Metabolic syndrome
- Moodiness
- Skin issues
- The urgency to use the bathroom
- Vitamin deficiencies
- Weight issues
Optimize natural GLP-1 and Butyrate With GutsyRx
Let’s set you up for success! GutsyRx provides guidance to prevent, support, and treatments to alleviate symptoms related to low GLP-1 and Butyrate. Treatments include this GLP-1 Natural Support Bundle as well as Ginger Gut Activator, Magnesium Replenish and Butyrate Suppositories. Lifestyle guidance may include discussing ways through diet and lifestyle to improve GLP-1 and butyrate levels. As a member, our lady gastroenterology doctors are available to you.
6 Sources
GutsyRx is committed to providing high-quality, reliable information to support women facing gut and rectal health challenges. Our content is curated and reviewed by women doctors to ensure it is accurate, trustworthy, and relevant. We strive to be a dependable resource, empowering women with the knowledge they need for better gut and rectal health.
- Hodgkinson, K., et al., Butyrate’s role in human health and the current progress towards its clinical application to treat gastrointestinal disease. Clin Nutr, 2023. 42(2): p. 61-75.
- Muller, T.D., et al., Glucagon-like peptide 1 (GLP-1). Mol Metab, 2019. 30: p. 72-130.
- Canani, R.B., et al., Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol, 2011. 17(12): p. 1519-28.
- Bodnaruc, A.M., et al., Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review. Nutr Metab (Lond), 2016. 13: p. 92.
- Mayorga-Ramos, A., et al., Protective role of butyrate in obesity and diabetes: New insights. Front Nutr, 2022. 9: p. 1067647.
- Recharla, N., R. Geesala, and X.Z. Shi, Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review. Nutrients, 2023. 15(10).
Taking care of your health is a revolutionary act. We’re here for it.
Meet Your Lady GI MD
Hi, I’m Dr. Emily Ward. I’m a board-certified gastroenterologist with 20+ years of professional experience and 30 + years of personal gut and rectal challenges. I am a mom of 2 kids with food allergies and a working mother navigating the everyday work-mom-life spectrum. With GutsyRx, I’m here to make sure you feel heard, seen, and cared for.
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